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Will Intra-osseous Injection of Umbilical Cord Blood Stem Cells Reduce Graft Failures?

Researchers from Italy have reported that the injection of umbilical cord blood stem cells directly into the pelvic bones of patients with leukemia appears promising. Transplantation of bone marrow, peripheral blood stem cells, and umbilical cord blood stem cells is accomplished by intravenous infusion. The original studies of human bone marrow transplantation were carried out by direct infusion into bone marrow spaces. However, this approach was abandoned as there was no advantage in speed or rate of engraftment over intravenous infusion. Since the early days of transplantation, there have been sporadic attempts to evaluate intra-osseous infusion of stem cells, but no advantage over intravenous infusion was ever found. The reason for this is thought to be that direct infusion of stem cells into the marrow cavity is in fact identical to intra-arterial or intra-venous infusion, and most stem cells enter the general circulation before homing into marrow spaces throughout the body.

Researchers from Italy have reported that the injection of umbilical cord blood stem cells directly into the pelvic bones of patients with leukemia appears promising. Transplantation of bone marrow, peripheral blood stem cells, and umbilical cord blood stem cells is accomplished by intravenous infusion. The original studies of human bone marrow transplantation were carried out by direct infusion into bone marrow spaces. However, this approach was abandoned as there was no advantage in speed or rate of engraftment over intravenous infusion. Since the early days of transplantation, there have been sporadic attempts to evaluate intra-osseous infusion of stem cells, but no advantage over intravenous infusion was ever found. The reason for this is thought to be that direct infusion of stem cells into the marrow cavity is in fact identical to intra-arterial or intra-venous infusion, and most stem cells enter the general circulation before homing into marrow spaces throughout the body.

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